Key result
Rotavirus protection against disease is induced by heterotypic strains and correlates with rotavirus-specific binding sIgA in feces, though protection can occur without detectable fecal sIgA.
Why the study?
What are the immunological determinants of protection against rotavirus infection and disease?
Population
Experimental animals and humans (infants and young children)
Design
Review
Authors
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May support heterotypic rotavirus vaccines; leaves open necessity of detectable fecal sIgA for protection.
What are the immunological determinants of protection against rotavirus infection and disease?
This review highlights that protection against rotavirus disease can be induced by heterotypic strains and that oral inoculation may not be strictly necessary for mucosal immunity.
Paul A. Offit (1994) conducted a review in Rotavirus infection. Rotavirus vaccines was evaluated. Rotavirus protection against disease is induced by heterotypic strains and correlates with rotavirus-specific binding sIgA in feces, though protection can occur without detectable fecal sIgA.
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