Why the study?
Does natural infection or vaccination induce immune resistance to rotavirus gastroenteritis in nursery children?
Population
Children in a welfare nursery experiencing outbreaks of gastroenteritis due to rotavirus serotype 1 or 3
Design
Cohort
Authors
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Serotype-specific, short-duration protection after natural infection cautions against assuming durable resistance; leaves open optimal vaccine strategies for broad heterotypic immunity.
Does natural infection or vaccination induce immune resistance to rotavirus gastroenteritis in nursery children?
Protection against rotavirus is serotype specific and related to homotypic antibody levels, though heterotypic responses suggest cross-immunity can be induced.
Chiba et al. (1993) studied this question.
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