Key result
Studies in the adult mouse model suggest that protection elicited by rotavirus immunization is multifactorial, involving CD8 and CD4 T cells as well as B cells.
Protection elicited by rotavirus vaccines in adult mouse models is multi-factorial, involving various lymphocyte populations depending on the specific immunogen and delivery route.
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Mouse model data indicate context-dependent immunity; leaves open translation to human rotavirus vaccine design.
Richard L. Ward (2003) conducted a review in Rotavirus disease. Rotavirus vaccines was evaluated. Studies in the adult mouse model suggest that protection elicited by rotavirus immunization is multifactorial, involving CD8 and CD4 T cells as well as B cells.
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