The Role of Serum Antibodies in the Protection against Rotavirus Disease: An Overview
Why the study?
Do serum antibodies protect against rotavirus disease in humans?
Population
Humans, including adult volunteers, young children, and infants, evaluated for rotavirus infection and…
Design
Review
Authors
Discussion
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Member takes
Implication
Supports serum antibodies as correlate for rotavirus vaccine trials; prospective studies needed to confirm causality.
Structured PICO
Do serum antibodies protect against rotavirus disease in humans?
P
Population
Humans, including adult volunteers, young children, and infants, evaluated for rotavirus infection and vaccination
I
Intervention
Serum antibodies (humoral immune response) following wild virus infection or oral live vaccines
O
Outcome
Protection against rotavirus disease
Serum antibodies are an important correlate of protection against rotavirus disease, supporting their relevance in evaluating vaccine efficacy.
Cite This Study
Jiang et al. (2002) studied this question.