Key result
Cypher1, a novel striated muscle-restricted protein, binds to alpha-actinin-2 and protein kinase C, suggesting it functions as an adaptor coupling PKC-mediated signaling to the cytoskeleton.
Population
Embryonic and adult cardiac and striated muscle models
Design
Preclinical
Authors
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May link PKC signaling to Z-line cytoskeleton in striated muscle; leaves open human cardiac disease relevance.
Identifies Cypher1 as a novel adaptor protein in striated muscle that couples protein kinase C signaling to the cytoskeleton.
Zhou et al. (1999) studied this question. Cypher1, a novel striated muscle-restricted protein, binds to alpha-actinin-2 and protein kinase C, suggesting it functions as an adaptor coupling PKC-mediated signaling to the cytoskeleton.
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