Key result
A semi-automatic rule-based method for generating human atrial myofiber orientations produced similar myo-bundle structures and activation sequences compared to image-based sheep atrial models.
Computational simulations demonstrate that human rule-based and sheep image-based atrial models share similar myo-bundle structures and preferential electrical propagation pathways.
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Supports scalable human atrial modeling; leaves open clinical translation pending human validation.
Zhao et al. (2012) studied Atrial rhythm disturbances. Semi-automatic rule-based method for generating multi-layer myofiber orientations vs. Image-based model from sheep atria using confocal surface microscopy was evaluated on Myofiber orientation and electrical activation sequence. A semi-automatic rule-based method for generating human atrial myofiber orientations produced similar myo-bundle structures and activation sequences compared to image-based sheep atrial models.
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