Key result
Canine crista terminalis myocytes had fewer interconnections (6.4 vs 11.3, P<0.05) and more end-to-end orientation compared to left ventricular myocytes, explaining higher conduction anisotropy.
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May explain regional conduction differences in canine atria; hypothesis-generating for human arrhythmia mechanisms and requires validation before clinical relevance.
Absolute Event Rate: 6.4% vs 11.3%
p-value: p=< .05
Saffitz et al. (1994) studied Canine atrial and ventricular myocardium. Crista terminalis (atrial myocardium) vs. Left ventricular myocardium was evaluated on Number of myocyte interconnections at gap junctions (p=< .05). Canine crista terminalis myocytes had fewer interconnections (6.4 vs 11.3, P<0.05) and more end-to-end orientation compared to left ventricular myocytes, explaining higher conduction anisotropy.
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