Key result
In subjects >60 years, 24-hour pulse pressure independently predicted resistance vessel media-lumen ratio, which was higher in hypertensive than normotensive subjects (18.6% vs 12.8%, P<0.01).
Population
32 subjects older than 60 years, including 21 hypertensive and 11 normotensive individuals.
Design
Cross-sectional
Authors
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24-h pulse pressure may mark resistance vessel remodeling in elderly hypertensives; leaves open causal role and need for prospective trials.
Cross-Sectional (n=32)
Absolute Event Rate: 18.6% vs 12.8%
p-value: p=<.01
In elderly subjects, pulse pressure is a significant independent predictor of resistance vessel structural adaptation, highlighting its importance in hypertensive vascular changes.
James et al. (1995) conducted a cross-sectional in Hypertension (n=32). Hypertension vs. Normotension was evaluated on Media-lumen ratio (p=<.01). In subjects >60 years, 24-hour pulse pressure independently predicted resistance vessel media-lumen ratio, which was higher in hypertensive than normotensive subjects (18.6% vs 12.8%, P<0.01).
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