Key result
Hypertensive patients with a pulse pressure ≥60 mmHg had significantly higher cardiac mass compared to those with pulse pressure <60 mmHg (148.8 vs 116.3 g/m2; P<0.01).
Why the study?
Does increased pulse pressure correlate with increased cardiac mass in patients with essential hypertension?
Population
47 subjects (11 normal subjects and 36 patients with sustained essential hypertension of similar age)
Comparison
Pulse pressure ≥ 60 mmHg (Group II) vs Pulse pressure < 60 mmHg and normal subjects
Design
Cross-sectional
Authors
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Supports pulse pressure assessment for hypertrophy risk in hypertension; hypothesis-generating and requires prospective validation before practice change.
Observational (n=47)
Does increased pulse pressure correlate with increased cardiac mass in patients with essential hypertension?
Absolute Event Rate: 148.8% vs 116.3%
p-value: p=<0.01
Increased pulse pressure in essential hypertension is associated with increased cardiac mass, independent of mean arterial pressure.
Pannier et al. (1989) conducted an observational in Essential hypertension (n=47). Pulse pressure ≥ 60 mmHg vs. Pulse pressure < 60 mmHg was evaluated on Cardiac mass (g/m2) (p=<0.01). Hypertensive patients with a pulse pressure ≥60 mmHg had significantly higher cardiac mass compared to those with pulse pressure <60 mmHg (148.8 vs 116.3 g/m2; P<0.01).
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