Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2/HO-1 pathway in preclinical models.
Does carnosic acid prevent doxorubicin-associated myocardiopathy?
Carnosic acid shows potential as a therapeutic strategy to prevent doxorubicin-induced cardiotoxicity by enhancing the Nrf2/HO-1 pathway.
activating the Nrf2-related cytoprotective system and protected the heart from oxidative damage, apoptosis, and pyroptosis, implying that the use of CA could be a potential therapeutic strategy in the prevention of DOX-associated myocardiopathy.
Hu et al. (Sun,) conducted a other in Doxorubicin-induced cardiotoxicity. Carnosic acid was evaluated. Carnosic acid protects against doxorubicin-induced cardiotoxicity through enhancing the Nrf2/HO-1 pathway in preclinical models.