Why the study?
Does bucindolol or carvedilol alter beta-adrenergic receptor density and gene expression in cultured cardiac myocytes?
Population
Cultured embryonic chick cardiac myocytes and hamster DDT1 MF2 cell line
Comparison
Bucindolol, carvedilol, or norepinephrine… vs Drug-untreated cells
Design
Preclinical
Follow-up
24 h
Authors
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Animal data on bucindolol receptor effects require human validation; leaves open differential actions versus carvedilol.
Does bucindolol or carvedilol alter beta-adrenergic receptor density and gene expression in cultured cardiac myocytes?
Bucindolol, unlike carvedilol, decreases beta-adrenergic receptor density in cultured cardiac myocytes through mechanisms distinct from agonist-induced downregulation.
Asano et al. (2001) studied this question.
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