Key result
US cancer and AF-related mortality increases ~102% over the study period.
Why the study?
AF and cancer share risk factors and may compound mortality risk, but national trends in AF and cancer-related mortality remain underexplored.
Population
US adults aged 25 years and older with AF and cancer as causes of death
Comparison
Demographic and geographic stratifications
Design
Retrospective epidemiological study using the CDC WONDER database
Authors
Loading...
May warrant integrated cardio-oncology vigilance; leaves open drivers of rising mortality and need for prospective studies.
Observational
Yes
Effect estimate: AAPC 3.49 (95% CI 3.39-3.60)
Absolute Event Rate: 10.01% vs 4.95%
Mortality from concurrent cancer and atrial fibrillation in the US has significantly increased from 1999 to 2019, with notable disparities across sex, race, and geography.
Saad et al. (2025) conducted an observational in Atrial fibrillation and cancer. Cancer and atrial fibrillation-related mortality in the US increased from 4.95 per 100,000 in 1999 to 10.01 in 2019 (average annual percentage change 3.49; 95% CI 3.39-3.60).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: