December 24, 2009Biomarkers
Atrial fibrillation after thoracic surgery for lung cancer: use of a single cut-off value of N-terminal pro-B type natriuretic peptide to identify patients at risk
Key result
A perioperative NT-proBNP cut-off of 182.3 ng/L provided the highest sensitivity and specificity for predicting postoperative atrial fibrillation, which occurred in 18% of patients.
Why the study?
Does NT-proBNP predict postoperative atrial fibrillation in lung cancer patients undergoing thoracic surgery?
Population
400 lung cancer patients undergoing thoracic surgery
Design
Cohort
Follow-up
postoperative period
Authors
Discussion
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Member takes
Implication
NT-proBNP may aid POAF risk stratification after thoracic surgery; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Observational (n=400)
Structured PICO
Does NT-proBNP predict postoperative atrial fibrillation in lung cancer patients undergoing thoracic surgery?
P
Population
400 lung cancer patients undergoing thoracic surgery
I
Intervention
NT-proBNP measurement before and after surgery
O
Outcome
Postoperative atrial fibrillation (AF)
A perioperative NT-proBNP cut-off of 182.3 ng/L can identify lung cancer patients at high risk for postoperative atrial fibrillation after thoracic surgery.
Cite This Study
Salvatici et al. (2009) conducted an observational in Lung cancer (n=400). NT-proBNP measurement was evaluated on Postoperative atrial fibrillation. A perioperative NT-proBNP cut-off of 182.3 ng/L provided the highest sensitivity and specificity for predicting postoperative atrial fibrillation, which occurred in 18% of patients.