Increased Perioperative N-Terminal Pro-B-Type Natriuretic Peptide Levels Predict Atrial Fibrillation After Thoracic Surgery for Lung Cancer
Key result
Elevated perioperative NT-proBNP strongly predicted postoperative atrial fibrillation compared to normal values (64% vs 5%; P<0.001) in patients undergoing thoracic surgery for lung cancer.
Why the study?
Does elevated perioperative NT-proBNP predict postoperative atrial fibrillation in patients undergoing thoracic surgery for lung cancer?
Population
400 patients undergoing thoracic surgery for lung cancer, mean age 62+/-10 years, 271 men.
Comparison
Elevated perioperative N-terminal pro-B-type… vs Normal perioperative NT-proBNP levels
Design
Cohort
Follow-up
postoperative period
Authors
Discussion
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Implication
May support perioperative NT-proBNP monitoring for postoperative AF risk; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Cohort (n=400)
Structured PICO
Does elevated perioperative NT-proBNP predict postoperative atrial fibrillation in patients undergoing thoracic surgery for lung cancer?
P
Population
400 patients undergoing thoracic surgery for lung cancer, mean age 62+/-10 years, 271 men.
I
Intervention
Elevated perioperative (24 hours before and 1 hour after surgery) N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels
C
Comparator
Normal perioperative NT-proBNP levels
O
Outcome
Incidence of postoperative atrial fibrillationhard clinical
Main Result
Effect estimate: RR 27.9 (95% CI 13.2 to 58.9)
Absolute Event Rate: 64% vs 5%
p-value: p=<0.001
Elevated perioperative NT-proBNP is a strong independent predictor of postoperative atrial fibrillation in patients undergoing thoracic surgery for lung cancer.
Cite This Study
Cardinale et al. (2007) conducted a cohort in Lung cancer undergoing thoracic surgery (n=400). Elevated perioperative NT-proBNP vs. Normal NT-proBNP values was evaluated on Incidence of postoperative atrial fibrillation (RR 27.9, 95% CI 13.2 to 58.9, p=<0.001). Elevated perioperative NT-proBNP strongly predicted postoperative atrial fibrillation compared to normal values (64% vs 5%; P<0.001) in patients undergoing thoracic surgery for lung cancer.