Key result
Chronic heart failure was associated with reduced isometric force and increased fatigue in the quadriceps, but normal function in the adductor pollicis compared to healthy volunteers.
Why the study?
Does skeletal muscle fatigue and force production differ between healthy volunteers and patients with mild or severe chronic heart failure in large versus small muscles?
Population
15 participants
Comparison
Measurement of skeletal muscle function in the… vs Healthy volunteers
Design
Cross-sectional
Authors
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May warrant cautious exercise prescription for large muscles in severe CHF; leaves open muscle-specific mechanisms for prospective validation.
Observational (n=15)
Does skeletal muscle fatigue and force production differ between healthy volunteers and patients with mild or severe chronic heart failure in large versus small muscles?
Skeletal muscle fatigue in chronic heart failure appears related to inadequate blood flow for large muscle masses and an intrinsic skeletal muscle abnormality revealed during circulatory occlusion.
Buller et al. (1991) conducted an observational in Chronic heart failure (n=15). Measurement of skeletal muscle function during control and circulatory occlusion vs. Healthy volunteers was evaluated on Skeletal muscle force production and fatigue. Chronic heart failure was associated with reduced isometric force and increased fatigue in the quadriceps, but normal function in the adductor pollicis compared to healthy volunteers.
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