Key result
Rat myocardial relaxation accelerates during auxovolumic phase transition, inversely correlating with minimum LV diastolic pressure.
Why the study?
The rate and depth of myocardial relaxation determine left ventricular filling in early diastole, motivating analysis of the relaxation phase.
May influence early diastolic filling assessment; leaves open translation of auxovolumic relaxation mechanisms from rats to human HF.
The rate and depth of myocardial relaxation determine left ventricular (LV) filling in early diastole. To analyze the relaxation phase, the method of logarithm of LV pressure fall in rats was used. A gradual acceleration of relaxation was found during the transition from the isovolumic phase to the auxovolumic phase, immediately before the opening of the atrioventricular valves. The relaxation rate constant in this phase has been inversely correlated with the values of the minimum LV diastolic pressure and LV endsystolic volume. The results suggest that the gradual acceleration of relaxation is due to the straightening of the spring-like structure of connectin (titin), which is compressed during contraction.
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Kapelko et al. (2023) studied Myocardial relaxation. Myocardial relaxation in rat hearts accelerated during the transition to the auxovolumic phase and inversely correlated with minimum left ventricular diastolic pressure and endsystolic volume.
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