Baseline Characteristics of the Diabetic Participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Key result
The ALLHAT study enrolled 15,297 high-risk hypertensive adults with diabetes (49.8% female) to evaluate the efficacy of chlorthalidone versus amlodipine, lisinopril, or doxazosin.
Why the study?
Do alternative antihypertensive therapies (amlodipine, lisinopril, doxazosin) compared to chlorthalidone reduce fatal and nonfatal CHD and combined cardiovascular events in hypertensive adults with diabetes?
Population
15,297 hypertensive adults with diabetes, ages >= 55 years, 50.2% male, 39.4% African-American, 17.7% Hispanic
Comparison
Alternative antihypertensive therapies: calcium… vs Diuretic (chlorthalidone)
Design
Cohort
Follow-up
planned average of 6 years
Authors
Discussion
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Implication
Baseline characteristics of this large diabetic hypertensive cohort are detailed; leaves open comparative efficacy of regimens pending outcome data.
Study Design
Type
Cohort (n=15,297)
Multicenter
Yes
Structured PICO
Do alternative antihypertensive therapies (amlodipine, lisinopril, doxazosin) compared to chlorthalidone reduce fatal and nonfatal CHD and combined cardiovascular events in hypertensive adults with diabetes?
P
Population
15,297 hypertensive adults with diabetes, ages >= 55 years (36.0% of the entire ALLHAT cohort), 50.2% male, 39.4% African-American, 17.7% Hispanic
I
Intervention
Alternative antihypertensive therapies: calcium channel blocker (amlodipine), ACE inhibitor (lisinopril), or alpha-adrenergic blocker (doxazosin)
C
Comparator
Diuretic (chlorthalidone)
O
Outcome
Incidence of fatal and nonfatal coronary heart disease (CHD) and combined cardiovascular events (fatal and nonfatal CHD, revascularization surgery, angina pectoris, congestive heart failure, and stroke)composite
This baseline report describes a large, diverse cohort of older diabetic patients with hypertension in the ALLHAT trial, which will provide valuable information on optimal antihypertensive therapy in this high-risk population.
Cite This Study
Barzilay et al. (2001) conducted a cohort in Hypertension and diabetes (n=15,297). Diuretic (chlorthalidone) vs. Calcium channel blocker (amlodipine), ACE inhibitor (lisinopril), and alpha-adrenergic blocker (doxazosin) was evaluated on Fatal and nonfatal coronary heart disease (CHD) and combined cardiovascular events. The ALLHAT study enrolled 15,297 high-risk hypertensive adults with diabetes (49.8% female) to evaluate the efficacy of chlorthalidone versus amlodipine, lisinopril, or doxazosin.