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Demonstrates efficient alignment of cDNA with genomic DNA, suggesting improved genetic analysis capabilities.
We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.
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Florea et al. (1998) studied this question.
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