What question did this study set out to answer?

The aim is to present a method for DNA sequencing that leverages computer programs to enhance genome analysis.

January 1, 1979Nucleic Acids Research397 citationsOpen Access

A strategy of DNA sequencing employing computer programs

RSRodger StadenCentre National de la Recherche Scientifique

Key Points

The aim is to present a method for DNA sequencing that leverages computer programs to enhance genome analysis.
Describes computer programs that order sequence gel readings and clones.
Introduces a coding method for managing uncertainties in gel readings.
Programs are available upon request for practical application.
Facilitates whole genome sequencing without the need for restriction maps.
Enhances accuracy in sequencing outcomes through better ordering methods.

Abstract

With modern fast sequencing techniques and suitable computer programs it is now possible to sequence whole genomes without the need of restriction maps. This paper describes computer programs that can be used to order both sequence gel readings and clones. A method of coding for uncertainties in gel readings is described. These programs are available on request.

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