Key result
Oral sodium nitrate trial reports no quantitative results for myocardial ischemia in stable angina.
Why the study?
Does oral sodium nitrate improve myocardial ischemia in patients with stable angina?
RCT
Double-blind
Crossover
Does oral sodium nitrate improve myocardial ischemia in patients with stable angina?
Reduces angina episodes in stable angina; extends evidence for oral nitrate supplementation in ischemic heart disease.
In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.
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Schwarz et al. (2016) conducted an RCT in Stable angina. Oral sodium nitrate vs. Placebo was evaluated on Myocardial ischemia. Oral sodium nitrate treatment is being investigated for its potential to improve myocardial ischemia in patients with stable angina, though the abstract reports no quantitative results.
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