Why the study?
Do clinical characteristics and in-hospital outcomes of acute heart failure patients in a real-world registry differ from those enrolled in a randomized controlled trial?
Population
1,162 patients with acute heart failure, comprising 697 patients from a complementary registry and 465…
Comparison
Real-world clinical registry care vs Enrollment in a randomized controlled trial
Design
Cohort
Follow-up
In-hospital
Authors
Discussion
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Member takes
Implication
Higher mortality in real-world registry versus RCT acute HF patients; leaves open the generalizability of trial findings.
Structured PICO
Do clinical characteristics and in-hospital outcomes of acute heart failure patients in a real-world registry differ from those enrolled in a randomized controlled trial?
P
Population
1,162 patients with acute heart failure, comprising 697 patients from a complementary registry (8 sites) and 465 patients from the ASCEND-HF RCT (31 Canadian sites).
I
Intervention
Real-world clinical registry care
C
Comparator
Enrollment in a randomized controlled trial (ASCEND-HF)
O
Outcome
In-hospital mortalityhard clinical
Patients enrolled in acute heart failure RCTs have significantly different clinical characteristics and lower in-hospital mortality compared to real-world registry patients, highlighting limitations in the generalizability of trial results.
Cite This Study
Ezekowitz et al. (2012) studied this question.