May 1, 2012Expert Review of Cardiovascular Therapy
The ASCEND-HF trial: an acute study of clinical effectiveness of nesiritide and decompensated heart failure
Key result
Nesiritide's safety and efficacy in acute decompensated heart failure, as evaluated in the landmark ASCEND-HF trial, are reviewed along with its potential evolving role in future therapy.
Why the study?
Does nesiritide improve clinical outcomes in patients with acute decompensated heart failure?
Population
Patients with acute decompensated heart failure
Design
Review
Authors
Discussion
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Member takes
Implication
Offers synthesis of ASCEND-HF lessons for ADHF; leaves open nesiritide's potential role pending further trials.
Structured PICO
Does nesiritide improve clinical outcomes in patients with acute decompensated heart failure?
P
Population
Patients with acute decompensated heart failure
I
Intervention
Nesiritide
O
Outcome
Safety and efficacy based on clinically relevant outcomes
This review summarizes the findings and lessons learned from the ASCEND-HF trial regarding the use of nesiritide in acute decompensated heart failure.
Cite This Study
Dandamudi et al. (2012) conducted a review in acute decompensated heart failure. nesiritide was evaluated. Nesiritide's safety and efficacy in acute decompensated heart failure, as evaluated in the landmark ASCEND-HF trial, are reviewed along with its potential evolving role in future therapy.