What question did this study set out to answer?

This research examines how dysglycemia influences infarct size and cardiovascular outcomes after acute myocardial infarction.

October 1, 2010Journal of Cardiovascular Magnetic ResonanceOpen Access

Relationship of dysglycemia to acute myocardial infarct size and cardiovascular outcome as determined by cardiovascular magnetic resonance

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Why the study?

Does dysglycemia or diabetes mellitus increase infarct size and worsen cardiovascular outcomes in patients with first acute myocardial infarction?

Population

93 patients with first acute myocardial infarction. Subgroups: 22 with diabetes mellitus, 13 with…

Comparison

Dysglycemia or diabetes mellitus vs Normoglycemia

Design

Cohort

Follow-up

11 months (CMR), 18 months (clinical)

Authors

AMAdam N MatherMediclinic City Hospital ACAndrew CreanCardiac Imaging NANik AbidinUniversity of Leeds

Discussion

Member takes

Implication

Dysglycemia was associated with larger post-AMI scars; leaves open whether glycemic control modifies remodeling or outcomes.

Key Points

This research examines how dysglycemia influences infarct size and cardiovascular outcomes after acute myocardial infarction.
Ninety-three patients with first acute myocardial infarction were examined.
Patients were categorized into three groups: diabetes mellitus, dysglycemia, and normoglycemia based on admission blood glucose levels.
Cardiac magnetic resonance imaging was performed to assess infarct size and left ventricular function at baseline and a median of 11 months follow-up.
Patients with dysglycemia had a mean LV scar percentage of 23.0% compared to 15.8% in normoglycemic patients (p=0.001).
At 11 months, LV scar percentage remained higher in dysglycemic patients (17.6%) versus normoglycemic patients (12.4%) (p=0.017).
Lower event-free survival rates were observed in dysglycemic and diabetic patients at 18 months (p=0.005).

Structured PICO

Does dysglycemia or diabetes mellitus increase infarct size and worsen cardiovascular outcomes in patients with first acute myocardial infarction?

Population

93 patients with first acute myocardial infarction (AMI). Subgroups: 22 with diabetes mellitus, 13 with dysglycemia, 58 with normoglycemia.

Intervention

Dysglycemia (admission blood glucose ≥ 7.8 mmol/l but < 11.1 mmol/l) or diabetes mellitus (prior history or admission blood glucose ≥ 11.1 mmol/l)

Comparator

Normoglycemia (admission blood glucose < 7.8 mmol/l)

Outcome

Infarct size (percentage LV scar) quantified by late gadolinium contrast-enhanced CMR at index presentation and median 11 months follow-upsurrogate

Dysglycemia and diabetes are associated with larger infarct sizes by CMR and worse event-free survival following a first AMI compared to normoglycemia.

Cite This Study

Mather et al. (2010) studied this question.

synapsesocial.com/papers/6a07f80709b3c82015378dbc https://doi.org/10.1186/1532-429x-12-61

Topics

Cardiac MRI

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Relationship of dysglycemia to acute myocardial infarct size and cardiovascular outcome as determined by cardiovascular magnetic resonance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Relationship of dysglycemia to acute myocardial infarct size and cardiovascular outcome as determined by cardiovascular magnetic resonance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider