Key result
Compared to normolipidemic controls, hypertensive patients with FCHL had 196% higher VLDL cholesterol (p=0.0001), 33% higher apolipoprotein B (p=0.0002), and 73% higher fasting insulin (p=0.003).
Observational (n=131)
Familial dyslipidemic hypertension consists of at least two subgroups with distinct lipid, anthropometric, and insulin profiles, suggesting different physiological mechanisms linking dyslipidemia, obesity, and hypertension.
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Should not yet change practice; supports hypothesis-generating subgroup distinctions in familial dyslipidemic hypertension.
Hunt et al. (1989) conducted an observational in Familial dyslipidemic hypertension (n=131). Familial combined hyperlipidemia (FCHL) subgroup vs. Normolipidemic hypertensive patients was evaluated on Apolipoprotein A-I and B, fasting plasma insulin, and anthropometrics. Compared to normolipidemic controls, hypertensive patients with FCHL had 196% higher VLDL cholesterol (p=0.0001), 33% higher apolipoprotein B (p=0.0002), and 73% higher fasting insulin (p=0.003).
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