Population
691 healthy villagers of Tecumseh, Michigan, average age 32.6 years, including 99 with clinical blood…
Design
Cross-sectional
Key result
Among untreated subjects with borderline hypertension, 37% exhibited a hyperkinetic state with elevated norepinephrine, suggesting sympathetic hyperactivity in mild blood pressure elevation.
Authors
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May suggest sympathetic overdrive in mild hypertension; hypothesis-generating and requires prospective trials before clinical consideration.
Observational (n=691)
No
A hyperkinetic state driven by sympathetic hyperactivity is present in a significant proportion of unselected subjects with mild blood pressure elevation.
Julius et al. (1991) conducted an observational in Borderline hypertension (n=691). Among untreated subjects with borderline hypertension, 37% exhibited a hyperkinetic state with elevated norepinephrine, suggesting sympathetic hyperactivity in mild blood pressure elevation.