Synthesis of Distal 1,4-Diaxial Atropisomers: CPA-Catalyzed Atroposelective (3 + 3)-Annulation via a Desymmetrization Strategy

Key Points

• This research focuses on synthesizing 1,4-diaxial atropisomers using a CPA-catalyzed strategy. The goal is to evaluate their utility in catalysis and emission properties.
• Utilized symmetric triol precursors for synthesis of BINCOLs.
• Conducted Cu-catalyzed enantioselective C-H thiolation of ferrocene carboxamide.
• Applied desymmetrization strategy in the reaction process.
• Demonstrated successful synthesis of 1,4-diaxial BINCOLs from symmetric triols.
• BINCOLs showed effectiveness in C-H thiolation, enhancing enantioselectivity.
• Exhibited aggregation-induced emission, suggesting innovation in polycyclic aromatic materials.