Key result
Addition of insulin to guinea-pig left atrial strips increased the force of contraction and enhanced the uptake of noradrenaline, leading to a diminished response to noradrenaline.
Why the study?
Does insulin alter the uptake of noradrenaline and the inotropic response in guinea-pig atrial strips?
Population
Guinea-pig left atrial strips driven electrically at 1 Hz
Comparison
Addition of insulin to the organ bath vs Atrial strips without insulin or response to…
Design
Preclinical
Authors
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Insulin's effects on guinea-pig atrial noradrenaline handling warrant human tissue studies; leaves open any clinical relevance in diabetes or heart failure.
Does insulin alter the uptake of noradrenaline and the inotropic response in guinea-pig atrial strips?
Insulin enhances the uptake of noradrenaline in atrial tissue, which may explain insulin-induced subsensitivity to noradrenaline.
Bhagat et al. (1981) studied Guinea-pig left atrial strips. Insulin vs. Absence of insulin was evaluated on Force of contraction and noradrenaline uptake. Addition of insulin to guinea-pig left atrial strips increased the force of contraction and enhanced the uptake of noradrenaline, leading to a diminished response to noradrenaline.
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