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May 16, 2026Investigative Radiology

Relaxivity Performance of Gadopiclenol Versus Gadobenate Dimeglumine In Vitro, and Liver and Brain Imaging

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Authors

JHJulius F. HeidenreichUniversity of Wisconsin–MadisonDTDaiki TamadaJRJames RiceUniversity of Wisconsin–Madison

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Implication

Randomized trial compares relaxivity in contrast agents and assesses imaging outcomes in liver and brain applications, suggesting optimal dosing strategies.

Key Points

  • The study aims to compare the relaxivity of gadopiclenol and gadobenate dimeglumine in vitro and assess their effects on liver and brain imaging.
  • Relaxivity was measured in saline, plasma, and blood at 1.5T and 3.0T
  • Participants underwent three MRI examinations with varying gadolinium doses in a randomized crossover design
  • Dynamic MRI assessed liver imaging and DSC perfusion metrics.
  • Higher r1, r2, and r2* values were observed for gadopiclenol across all media tested (R²>0.98)
  • 0.1mmol/kg gadopiclenol showed significantly greater liver enhancement compared to gadobenate dimeglumine
  • DSC perfusion metrics indicated that 0.05mmol/kg gadopiclenol reduced AIF peak and AUC significantly.

Cite This Study

Heidenreich et al. (2026) studied this question.

synapsesocial.com/papers/6a080b4ea487c87a6a40d853https://doi.org/10.1097/rli.0000000000001295
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