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May 16, 2026OpenNanoOpen Access

Spanlastics as an efficient delivery system for the enhancement of Nilotinib anticancer efficacy: Design, fabrication, and cytotoxic studies against chronic myeloid leukemia

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Authors

M‎Mohammed Layth ‎HamzahRMRaffah Khamis MahalIAIshraq Kadhim Abbas

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Overview

Randomized trial assesses oral bioavailability and cytotoxicity of NLT-loaded spanlastics in chronic myeloid leukemia, suggesting improved treatment outcomes.

Key Points

  • The aim is to optimize NLT-loaded spanlastics to enhance oral bioavailability and therapeutic efficacy of Nilotinib for chronic myeloid leukemia.
  • Optimized NLT-SPLs using Box-Behnken design
  • Conducted pharmacokinetic studies and in vitro cytotoxicity assays
  • Characterized vesicles for size, stability, and drug release
  • Optimized NLT-SPLs increased oral bioavailability by 2.5-fold compared to NLT suspension
  • Significantly extended Tmax and sustained plasma drug concentrations
  • NLT-SPL showed superior cytotoxicity against HL-60 and HEL cells with improved Caco-2 permeability

Cite This Study

‎Hamzah et al. (2026) studied this question.

synapsesocial.com/papers/6a080b84a487c87a6a40da7bhttps://doi.org/10.1016/j.onano.2026.100307
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