Arrhythmogenic right ventricular dysplasia, a cell adhesion cardiomyopathy: insights into disease pathogenesis from preliminary genotype—phenotype assessment: Figure 1
Key result
Mutations affecting the outer dense plaque of the desmosome result in typical ARVC, while inner dense plaque mutations may cause predominantly left ventricular involvement.
Population
Patients with Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC)
Design
Review
Authors
Discussion
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Implication
Different mutations in desmosomal proteins lead to distinct phenotypic presentations of ARVC, with inner dense plaque mutations causing more left ventricular involvement.
Structured PICO
P
Population
Patients with Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC)
Different mutations in desmosomal proteins lead to distinct phenotypic presentations of ARVC, with inner dense plaque mutations causing more left ventricular involvement.
Cite This Study
Tsatsopoulou et al. (2006) conducted a review in Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC). Mutations affecting the outer dense plaque of the desmosome result in typical ARVC, while inner dense plaque mutations may cause predominantly left ventricular involvement.