No detection of enteroviral genome in the myocardium of patients with arrhythmogenic right ventricular cardiomyopathy
Key result
Analysis of endomyocardial tissue using nested PCR found no enteroviral genome in any of the 20 patients with ARVC or 20 control subjects, indicating enteroviruses are not involved in ARVC.
Why the study?
Is the presence of enteroviral genome in the myocardium associated with arrhythmogenic right ventricular cardiomyopathy?
Population
20 patients with arrhythmogenic right ventricular cardiomyopathy and 20 control subjects with other cardiac…
Comparison
Endomyocardial tissue analysis using reverse… vs Endomyocardial tissue from 20 control subjects…
Design
Case-control
Authors
Discussion
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Member takes
Implication
No enteroviral genome in ARVC myocardium; leaves open non-viral etiologies for larger confirmatory studies.
Study Design
Type
Case-Control (n=40)
Structured PICO
Is the presence of enteroviral genome in the myocardium associated with arrhythmogenic right ventricular cardiomyopathy?
P
Population
20 patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) (11 male, 9 female; mean age 40 years, SD 16) and 20 control subjects with other cardiac diseases.
I
Intervention
Endomyocardial tissue analysis using reverse transcription and nested polymerase chain reaction (PCR) for enteroviruses.
C
Comparator
Endomyocardial tissue from 20 control subjects with other cardiac diseases.
O
Outcome
Presence of enteroviral genome in endomyocardial tissue.surrogate
Main Result
Absolute Event Rate: 0% vs 0%
Enteroviral genome was not detected in the myocardium of ARVC patients, suggesting enteroviruses are not involved in its etiopathogenesis.
Cite This Study
Calabrese et al. (2000) conducted a case-control in Arrhythmogenic right ventricular cardiomyopathy (ARVC) (n=40). Reverse transcription and nested PCR for enteroviruses vs. Control subjects with other cardiac diseases was evaluated on Presence of enteroviral genome in endomyocardial tissue. Analysis of endomyocardial tissue using nested PCR found no enteroviral genome in any of the 20 patients with ARVC or 20 control subjects, indicating enteroviruses are not involved in ARVC.