What does this research mean for the field?

Coxsackievirus RNA is present in the myocardium of a significant proportion of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC), supporting a potential infectious etiology for the disease. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To investigate whether enteroviral genomes are present in the myocardial tissue of patients diagnosed with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

January 1, 1998Cardiology

Coxsackievirus Genome in Myocardium of Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

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Why the study?

Is the presence of coxsackievirus genome in the myocardium associated with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC)?

Population

36 patients undergoing endomyocardial biopsy, including 8 with arrhythmogenic right ventricular…

Comparison

Endomyocardial biopsy analysis for the presence… vs Patients with non-infectious myocardial diseases…

Design

Case-control

Authors

IGIsabella M. GrumbachABB (United States)AHAlbert HeimMedizinische Hochschule Hannover SVStefan VonhofEssen University Hospital

Discussion

Member takes

Implication

Supports viral pathogenesis hypothesis in ARVC; hypothesis-generating and should not yet change practice.

Key Points

To investigate whether enteroviral genomes are present in the myocardial tissue of patients diagnosed with arrhythmogenic right ventricular dysplasia/cardiomyopathy.
Examined endomyocardial biopsy samples from patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (N=8), myocarditis or dilated cardiomyopathy (N=23), and non-inflammatory heart conditions (N=5).
Tested cardiac biopsy specimens for the presence of enteroviral RNA sequences homologous to Coxsackievirus type B.
Detected enteroviral RNA in 3 of 8 patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (37.5%) and in 7 of 23 patients with myocarditis or dilated cardiomyopathy (30.4%).
Found no enteroviral genome in any of the 5 control patients with non-infectious myocardial diseases (0.0%), representing a significant difference compared to arrhythmogenic right ventricular dysplasia/cardiomyopathy patients (p < 0.05).

Structured PICO

Is the presence of coxsackievirus genome in the myocardium associated with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC)?

Population

36 patients undergoing endomyocardial biopsy, including 8 with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC), 23 with myocarditis or dilated cardiomyopathy (DCM), and 5 with non-inflammatory cardiac disorders.

Intervention

Endomyocardial biopsy analysis for the presence of enteroviral genome (coxsackievirus type B RNA).

Comparator

Patients with non-infectious myocardial diseases (n=5) and patients with myocarditis or DCM (n=23).

Outcome

Presence of enteroviral RNA with homology to coxsackieviruses type B in endomyocardial biopsies.surrogate

The detection of coxsackievirus type B RNA in the myocardium of ARVC patients supports the hypothesis that viral infection may be related to the pathogenesis of ARVC.

Cite This Study

Grumbach et al. (1998) studied this question.

synapsesocial.com/papers/6a189d4e673175fe754aaeea https://doi.org/10.1159/000006794

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Coxsackievirus Genome in Myocardium of Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coxsackievirus Genome in Myocardium of Patients with Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider