Key result
Exercise-induced arrhythmogenic cardiomyopathy shares ECG features with genetic disease, including ~80% ventricular arrhythmia rates.
Why the study?
The right ventricle can be susceptible to pathologic alterations with exercise causing ECG changes, and the electrocardiographic phenotype of exercise-induced arrhythmogenic cardiomyopathy needed identification.
Does the electrocardiographic phenotype during exercise differ between exercise-induced arrhythmogenic cardiomyopathy, genetic arrhythmogenic cardiomyopathy, and healthy controls?
Design
Retrospective observational study
Authors
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ECG overlap supports shared pathogenesis in exercise-induced arrhythmogenic cardiomyopathy; leaves open prospective validation for diagnosis and management.
Observational (n=63)
Yes
Does the electrocardiographic phenotype during exercise differ between exercise-induced arrhythmogenic cardiomyopathy, genetic arrhythmogenic cardiomyopathy, and healthy controls?
Absolute Event Rate: 80% vs 88%
p-value: p=<0.001
Exercise-induced arrhythmogenic cardiomyopathy shares important ECG features with genetic ACM, including a paradoxically low R/L duration ratio at peak exercise, suggesting a similar underlying pathogenesis.
Miljoen et al. (2022) conducted an observational in Arrhythmogenic cardiomyopathy (ACM) (n=63). Exercise-induced ACM (ExI-ACM) vs. Genetically confirmed ACM (Gen-ACM), endurance athletes, and sedentary individuals was evaluated on Presence of ventricular arrhythmias (p=<0.001). Exercise-induced arrhythmogenic cardiomyopathy shares important electrocardiographic features with genetically confirmed disease, including high rates of ventricular arrhythmias (80% vs 88%).
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