Key result
Higher post-diagnosis exercise in arrhythmogenic cardiomyopathy is linked to a greater rise in abnormal ECGs.
Why the study?
Exercise may modulate the pathogenesis of arrhythmogenic cardiomyopathy, but its impact on longitudinal ECG progression required assessment.
Does higher exercise exposure after diagnosis increase ECG progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy?
Population
163 patients with definitive ACM or pathogenic/likely pathogenic variants with negative/borderline phenotype
Comparison
Higher exercise vs lower exercise groups based on post-diagnosis exercise intensity
Design
Retrospective longitudinal cohort study
Follow-up
Average 4.6±2.5 years
Authors
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Exercise may modify ACM ECG progression; leaves open causality and optimal activity guidance pending trials.
Cohort (n=163)
Does higher exercise exposure after diagnosis increase ECG progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy?
Higher exercise exposure after diagnosis in patients with arrhythmogenic cardiomyopathy is associated with a greater prevalence of abnormal ECGs over time, supporting the need for regular ECG surveillance and individualized exercise recommendations.
Sriskandarajah et al. (2026) conducted a cohort in Arrhythmogenic cardiomyopathy (n=163). Higher exercise intensity vs. Lower exercise intensity was evaluated on Major ventricular arrhythmia, appropriate implantable cardioverter-defibrillator interventions, sudden cardiac arrest and sudden cardiac death. Higher post-diagnosis exercise exposure in patients with arrhythmogenic cardiomyopathy was associated with a significantly greater rise in the prevalence of abnormal ECGs at follow-up (p=0.027).
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