Key result
Infarcted ventricular tissues from 12 patients showed heterogeneous electrophysiology, including prolonged action potentials and slow response potentials, providing a likely substrate for arrhythmias.
Observational (n=12)
Heterogeneous electrophysiologic characteristics in infarcted human ventricular tissue provide a likely cellular substrate for ventricular arrhythmias.
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May underlie post-MI ventricular arrhythmias; leaves open targeted interventions pending prospective trials.
Spear et al. (1979) conducted an observational in Myocardial infarction (n=12). Microelectrode tissue bath analysis vs. Noninfarcted papillary muscles was evaluated on Electrophysiologic characteristics of ventricular tissues. Infarcted ventricular tissues from 12 patients showed heterogeneous electrophysiology, including prolonged action potentials and slow response potentials, providing a likely substrate for arrhythmias.
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