Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 17, 2019Heart Failure ReviewsOpen Access

Patients with high-dose diuretics should get ultrafiltration in the management of decompensated heart failure: a meta-analysis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Identifying specific patients with decompensated heart failure who may benefit from ultrafiltration is important in clinical practice.

Does ultrafiltration improve clinical outcomes compared to diuretics in patients with decompensated heart failure?

Population

975 patients with HF across 14 trials

Comparison

Ultrafiltration vs diuretics

Design

Meta-analysis of 14 trials

Authors

XSXiaofeng ShiNanjing Agricultural UniversityJBJiating BaoNankai UniversityHZHaili ZhangShanghai Jiao Tong University

Discussion

Loading...

Member takes

Overview

Supports ultrafiltration to reduce HF rehospitalizations; extends pooled evidence from 14 trials versus diuretics.

Structured PICO

Does ultrafiltration improve clinical outcomes compared to diuretics in patients with decompensated heart failure?

P
Population
14 trials pooling 975 patients with decompensated heart failure (DHF)
I
Intervention
Ultrafiltration
C
Comparator
Diuretic therapy (including subgroup analysis of high-dose >200 mg/day vs low-dose <200 mg/day)
O
Outcome
Major clinical outcomes including weight change, length of hospital stay, rehospitalization for HF, mortality, change in serum creatinine, dialysis dependence, and adverse outcomes

Ultrafiltration reduces heart failure rehospitalizations compared to diuretics in decompensated heart failure, and may be particularly indicated for patients requiring high-dose diuretics who are at risk for worsening renal function.

Cite This Study

Shi et al. (2019) studied this question.

synapsesocial.com/papers/6a082498df3db87398107df5https://doi.org/10.1007/s10741-019-09812-2

Topics

HFrEF treatmentHeart failureHeart failure hospitalization
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[The efficacy and safety of ultrafiltration for patients with heart failure: results from a single-center randomized controlled study].2017 · 5 citations
  2. 2Worsening Renal Failure in Patients with Acute Heart Failure: The Importance of Cardiac Biomarkers2019 · 34 citations
  3. 3Effect of Ultrafiltration versus Intravenous Furosemide for Decompensated Heart Failure in Cardiorenal Syndrome: A Systematic Review with Meta-Analysis of Randomized Controlled Trials2015 · 19 citations
  4. 4Ultrafiltration in the management of acute decompensated heart failure2010 · 9 citations
  5. 5Ultrafiltration Versus Usual Care for Hospitalized Patients With Heart Failure2005 · 420 citations