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September 11, 2008Current Opinion in Critical Care

Ultrafiltration in the management of heart failure

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Why the study?

Does ultrafiltration improve weight and fluid loss and reduce rehospitalizations compared to intravenous diuretics in patients hospitalized for acute decompensated heart failure?

Population

200 volume overloaded heart failure patients hospitalized for acute decompensated heart failure

Comparison

Ultrafiltration vs Intravenous diuretics

Design

Review, randomized

Follow-up

90 days

Authors

MCMaria Rosa Costanzo

Discussion

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Overview

May support ultrafiltration for decongestion in acute HF; leaves open confirmation of rehospitalization benefit in randomized trials.

Structured PICO

Does ultrafiltration improve weight and fluid loss and reduce rehospitalizations compared to intravenous diuretics in patients hospitalized for acute decompensated heart failure?

P
Population
200 volume overloaded heart failure patients hospitalized for acute decompensated heart failure
I
Intervention
Ultrafiltration
C
Comparator
Intravenous diuretics
O
Outcome
48 h weight and net fluid losssurrogate

In decompensated heart failure, ultrafiltration safely produces greater weight and fluid loss than intravenous diuretics and reduces rehospitalization rates.

Cite This Study

Maria Rosa Costanzo (2008) studied this question.

synapsesocial.com/papers/6a8696a39ce8d1ef366ed38dhttps://doi.org/10.1097/mcc.0b013e328309a481
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ultrafiltration Versus Intravenous Diuretics for Patients Hospitalized for Acute Decompensated Heart Failure2007 · 1,122 citations
  2. 2Ultrafiltration Versus Usual Care for Hospitalized Patients With Heart Failure2005 · 419 citations
  3. 3Extracorporeal Ultrafiltration for the Treatment of Overhydration and Congestive Heart Failure2001 · 102 citations
  4. 4Isolation of “Myocardial Depressant Factor(s)” From the Ultrafiltrate of Heart Failure Patients With Acute Renal Failure1996 · 91 citations
  5. 5Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD).1990 · 1,393 citations