August 1, 1978CirculationOpen Access

Severe aortic stenosis with impaired left ventricular function and clinical heart failure: results of valve replacement.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Severe aortic stenosis with impaired left ventricular function and clinical heart failure (n=19). Intervention: Aortic valve replacement. Primary outcome: Three-year survival.

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Key result

Aortic valve replacement in patients with severe aortic stenosis and heart failure resulted in a 74% three-year survival and marked improvement in left ventricular ejection fraction (0.34 to 0.63).

Why the study?

Does aortic valve replacement improve survival and left ventricular function in patients with severe aortic stenosis and clinical heart failure?

Population

19 patients, aged 58-80 years, with severe isolated aortic valve stenosis, severely reduced ejection…

Design

Case_series

Follow-up

6 to 74 months (mean 38 +/- 6 months)

Authors

NSNeale D. SmithUniversity of New Mexico JMJohn H. McAnultyElectrophysiology SRS H RahimtoolaUniversity of Southern California

Discussion

Member takes

Implication

Supports AVR consideration in severe AS with HF; leaves open need for modern randomized confirmation.

Key Points

This study aims to evaluate the outcomes of aortic valve replacement in patients with severe aortic stenosis and impaired left ventricular function.
Nineteen patients aged 58-80 underwent aortic valve replacement from January 1970 to April 1977.
Ten patients had coronary artery disease, all receiving additional bypass surgery.
Follow-up assessments included hemodynamic evaluations and functional class classifications over 3-5 years.
Three-year survival rate is 74 +/- 10%, with an expected five-year survival being similar.
Functional classifications improved, with six patients moving to Class I and seven to Class II from higher initial classes.
Left ventricular ejection fraction significantly increased from 0.34 +/- 0.03 to 0.63 +/- 0.05 post-surgery.

Study Design

Type

Cohort (n=19)

Structured PICO

Does aortic valve replacement improve survival and left ventricular function in patients with severe aortic stenosis and clinical heart failure?

Population

19 patients, aged 58-80 years, with severe isolated aortic valve stenosis, severely reduced ejection fraction, and clinical heart failure.

Intervention

Aortic valve replacement (with concomitant coronary bypass surgery in 10 patients with coronary artery disease).

Outcome

Survival, functional class (NYHA), and left ventricular function/hemodynamics.hard clinical

Aortic valve replacement in patients with severe aortic stenosis and clinical heart failure yields encouraging long-term survival and marked improvement in left ventricular function.

Cite This Study

Smith et al. (1978) conducted a cohort in Severe aortic stenosis with impaired left ventricular function and clinical heart failure (n=19). Aortic valve replacement was evaluated on Three-year survival. Aortic valve replacement in patients with severe aortic stenosis and heart failure resulted in a 74% three-year survival and marked improvement in left ventricular ejection fraction (0.34 to 0.63).

synapsesocial.com/papers/6a082762ab15ea61dee8b18e https://doi.org/10.1161/01.cir.58.2.255

Topics

Heart failure HFrEF treatment

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August 1, 1978CirculationOpen Access

Severe aortic stenosis with impaired left ventricular function and clinical heart failure: results of valve replacement.

View Full Paper

Ask AI

Bookmark

Key result

Aortic valve replacement in patients with severe aortic stenosis and heart failure resulted in a 74% three-year survival and marked improvement in left ventricular ejection fraction (0.34 to 0.63).

Why the study?

Does aortic valve replacement improve survival and left ventricular function in patients with severe aortic stenosis and clinical heart failure?

Population

19 patients, aged 58-80 years, with severe isolated aortic valve stenosis, severely reduced ejection…

Design

Case_series

Follow-up

6 to 74 months (mean 38 +/- 6 months)

Authors

NSNeale D. SmithUniversity of New Mexico JMJohn H. McAnultyElectrophysiology SRS H RahimtoolaUniversity of Southern California

Discussion

Member takes

Implication

Supports AVR consideration in severe AS with HF; leaves open need for modern randomized confirmation.

Key Points

This study aims to evaluate the outcomes of aortic valve replacement in patients with severe aortic stenosis and impaired left ventricular function.
Nineteen patients aged 58-80 underwent aortic valve replacement from January 1970 to April 1977.
Ten patients had coronary artery disease, all receiving additional bypass surgery.
Follow-up assessments included hemodynamic evaluations and functional class classifications over 3-5 years.
Three-year survival rate is 74 +/- 10%, with an expected five-year survival being similar.
Functional classifications improved, with six patients moving to Class I and seven to Class II from higher initial classes.
Left ventricular ejection fraction significantly increased from 0.34 +/- 0.03 to 0.63 +/- 0.05 post-surgery.

Study Design

Type

Cohort (n=19)

Structured PICO

Does aortic valve replacement improve survival and left ventricular function in patients with severe aortic stenosis and clinical heart failure?

Population

19 patients, aged 58-80 years, with severe isolated aortic valve stenosis, severely reduced ejection fraction, and clinical heart failure.

Intervention

Aortic valve replacement (with concomitant coronary bypass surgery in 10 patients with coronary artery disease).

Outcome

Survival, functional class (NYHA), and left ventricular function/hemodynamics.hard clinical

Aortic valve replacement in patients with severe aortic stenosis and clinical heart failure yields encouraging long-term survival and marked improvement in left ventricular function.

Cite This Study

synapsesocial.com/papers/6a082762ab15ea61dee8b18e https://doi.org/10.1161/01.cir.58.2.255

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Heart failure HFrEF treatment

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