Key result
SAVR for predominant AI is linked to lower survival with moderate or greater concomitant AS.
Why the study?
Does surgical aortic valve replacement yield different survival and echocardiographic outcomes in patients with mixed aortic valve disease compared to those with isolated aortic valve lesions?
Cohort (n=1,011)
Does surgical aortic valve replacement yield different survival and echocardiographic outcomes in patients with mixed aortic valve disease compared to those with isolated aortic valve lesions?
p-value: p=0.02
Surgical AVR provides equivalent survival for predominant AS regardless of concomitant AI severity, but predominant AI with significant concomitant AS is associated with reduced survival post-AVR.
Authors
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May indicate higher post-AVR risk in predominant AI with moderate or greater AS; hypothesis-generating and should not yet change practice.
Philip et al. (2018) conducted a cohort in Mixed aortic valve disease (n=1,011). Surgical aortic valve replacement (AVR) vs. Predominant lesion with mild/less vs moderate/greater concomitant mixed valve disease was evaluated on Survival (p=0.02). Surgical aortic valve replacement for predominant aortic insufficiency with moderate or greater aortic stenosis was associated with lower survival compared to those with mild or less AS (P=0.02).
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