Key result
Long-term weight change over 15 years significantly predicted changes in eight coronary disease risk factors, with age modifying its effects on fasting glucose, uric acid, and forced vital capacity.
Why the study?
Does long-term weight change predict changes in coronary disease risk factors in men?
Population
1,396 men participating in the Veterans Administration Normative Aging Study in Boston, Massachusetts
Design
Cohort
Follow-up
15 years
Authors
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Weight change was associated with coronary risk factor shifts in men; extends prior data but leaves open causal effects and targeted interventions.
Cohort (n=1,396)
No
Does long-term weight change predict changes in coronary disease risk factors in men?
Long-term weight change is a significant independent predictor of changes in multiple coronary disease risk factors, with age modifying the effects on glucose, uric acid, and lung capacity.
Borkan et al. (1986) conducted a cohort in Coronary disease risk factors (n=1,396). Long-term weight change was evaluated on Change in eight putative coronary disease risk factors (blood pressure, serum cholesterol, triglycerides, fasting and two-hour postprandial blood glucose, uric acid, and forced vital capacity). Long-term weight change over 15 years significantly predicted changes in eight coronary disease risk factors, with age modifying its effects on fasting glucose, uric acid, and forced vital capacity.
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