Key result
Cardiac MRI accurately quantified in vivo cardiac mass in mice, showing excellent agreement with postmortem heart weight (r = 0.996) and detecting dose-dependent hypertrophy.
Why the study?
Can cardiac MRI accurately quantify in vivo cardiac mass in normal and hypertrophied mouse hearts compared to postmortem weight?
Population
Normal and hypertrophied mouse heart models
Comparison
Cardiac MRI gated to cardiac and respiratory… vs Postmortem heart weight
Design
Preclinical
Authors
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Supports noninvasive serial phenotyping in murine hypertrophy models; leaves open clinical translation.
Can cardiac MRI accurately quantify in vivo cardiac mass in normal and hypertrophied mouse hearts compared to postmortem weight?
Effect estimate: r = 0.996
Cardiac MRI can accurately and noninvasively quantify in vivo cardiac mass in normal and hypertrophied mouse models, showing excellent correlation with postmortem weight.
Slawson et al. (1998) studied Normal and hypertrophied mouse heart. Cardiac MRI vs. Postmortem heart weight was evaluated on Agreement between MRI-determined and postmortem heart weight (r = 0.996). Cardiac MRI accurately quantified in vivo cardiac mass in mice, showing excellent agreement with postmortem heart weight (r = 0.996) and detecting dose-dependent hypertrophy.
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