April 24, 2007NMR in Biomedicine
MR in mouse models of cardiac disease
Population
Transgenic and knockout mouse models of cardiac disease
Design
Review
Authors
Discussion
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Member takes
Implication
Supports broader adoption of MRI/MRS in cardiovascular mouse research; leaves open direct clinical translation.
Structured PICO
P
Population
Transgenic and knockout mouse models of cardiac disease
I
Intervention
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS)
O
Outcome
Quantitative or semi-quantitative in vivo assessment of cardiac anatomy, function, perfusion, infarction, Ca(2+) influx, and metabolismsurrogate
MRI and MRS are valuable non-invasive tools for phenotyping genetically engineered mouse models in cardiovascular research.
Cite This Study
Frederick H. Epstein (2007) studied this question.