Key result
In vivo cardiac 1H-MRS successfully quantifies metabolites and detects decreased myocardial creatine in GAMT-deficient mice.
Population
Normal C57Bl/6J mice and a murine model of guanidinoacetate N-methyltransferase deficiency
Design
Preclinical
Authors
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Enables noninvasive metabolic phenotyping in murine models; leaves open translation to clinical cardiac MRS applications.
This study demonstrates the first successful application of in vivo cardiac 1H-MRS in mice, enabling noninvasive investigation of metabolic phenotypes.
Schneider et al. (2004) studied Normal and GAMT-deficient mice. Cardiac 1H-MRS was evaluated on Detection and quantification of cardiac metabolites. In vivo cardiac 1H-MRS successfully detected and quantified cardiac metabolites in normal mice and confirmed decreased myocardial creatine levels in a murine model of GAMT deficiency.
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