What does this research mean for the field?

In non-insulin-dependent diabetes mellitus, the glomerular filtration rate is elevated at disease onset and during microalbuminuria, but declines progressively once macroalbuminuria develops. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to clarify the progression and determinants of renal disease in individuals with non-insulin-dependent diabetes mellitus.

November 28, 1996New England Journal of Medicine

Development and Progression of Renal Disease in Pima Indians with Non-Insulin-Dependent Diabetes Mellitus

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This research aims to clarify the progression and determinants of renal disease in individuals with non-insulin-dependent diabetes mellitus.
Studied 194 Pima Indians over 4 years assessing glomerular function every 6 to 12 months.
Measured glomerular filtration rate, renal plasma flow, urinary albumin excretion, and blood pressure.
Participants varied in diabetes stages from normal glucose tolerance to macroalbuminuria.
Initial mean glomerular filtration rate was 143 ml/min for newly diagnosed diabetes, 155 ml/min for microalbuminuria, and 124 ml/min for macroalbuminuria.
After 4 years, glomerular filtration rate increased by 18% in newly diagnosed diabetes (P=0.008) but declined by 35% in macroalbuminuria (P<0.001).
Higher baseline blood pressure correlated with increased urinary albumin excretion (P=0.006) and higher baseline albumin predictively led to a decline in glomerular filtration rate (P<0.001).

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Implication

Randomized trial observes renal disease progression in Pima Indians, indicating significant predictors affecting outcomes.

Cite This Study

Nelson et al. (1996) studied this question.

synapsesocial.com/papers/6a0841b3ef79633196e8ac4b https://doi.org/10.1056/nejm199611283352203

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Development and Progression of Renal Disease in Pima Indians with Non-Insulin-Dependent Diabetes Mellitus

Key Points

Discussion

Implication

Cite This Study

Development and Progression of Renal Disease in Pima Indians with Non-Insulin-Dependent Diabetes Mellitus

Key Points

Discussion

Implication

Cite This Study

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