Key result
Multiple sclerosis is linked to CV complications including autonomic dysfunction, Takotsubo syndrome, and therapy-induced cardiotoxicity.
Why the study?
Multiple sclerosis may be associated with cardiovascular diseases, but scarce attention has been given to this issue despite increasing patient lifespan.
This review highlights the importance of a multidisciplinary approach to managing cardiovascular complications and risk factors in patients with multiple sclerosis.
Multiple sclerosis (MS) is a chronic neurological disorder characterized by inflammation in the central nervous system (CNS) that leads to neurodegeneration. The clinical course is highly variable, but its prevalence is rising worldwide, partly thanks to novel disease-modifying therapies. Additionally, the lifespan of people with MS is increasing, and for this reason, it is fundamental to have a multidisciplinary approach to MS. MS may be associated with cardiovascular diseases (CVD), but there is scarce attention on this issue. In particular, CNS is essential in regulating the autonomic system and heart activity. Moreover, cardiovascular risk factors show a higher prevalence in MS patients. On the other hand, conditions like Takotsubo syndrome are rare complications of MS. The parallelism between MS and myocarditis is also interesting. Finally, cardiac toxicity represents a not infrequent adverse reaction to MS drugs. This narrative review aims to provide an overview of cardiovascular complications in MS and their management to prompt further clinical and pre-clinical research on this topic.
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Zavarella et al. (2023) conducted a review in Multiple sclerosis. Multiple sclerosis is associated with cardiovascular complications, including autonomic dysfunction, increased cardiovascular risk factors, Takotsubo syndrome, and cardiac toxicity from MS therapies.
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