Key result
Inflammation-metabolism interplay underlies CVD pathophysiology, offering new therapeutic targets for HF.
Why the study?
The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in cardiovascular diseases including heart failure, motivating an overview of this immuno-metabolic interface.
This review highlights the critical role of the immuno-metabolic interface in the pathophysiology of cardiovascular diseases, particularly heart failure, and discusses emerging therapeutic approaches.
May support immuno-metabolic targets in heart failure; leaves open prospective validation before practice change.
The interplay between the cardiovascular system, metabolism, and inflammation plays a central role in the pathophysiology of a wide spectrum of cardiovascular diseases, including heart failure. Here, we provide an overview of the fundamental aspects of the interrelation between inflammation and metabolism, ranging from the role of metabolism in immune cell function to the processes how inflammation modulates systemic and cardiac metabolism. Furthermore, we discuss how disruption of this immuno-metabolic interface is involved in the development and progression of cardiovascular disease, with a special focus on heart failure. Finally, we present new technologies and therapeutic approaches that have recently emerged and hold promise for the future of cardiovascular medicine.
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Bertero et al. (2021) conducted a review in Cardiovascular disease and heart failure. The interplay between inflammation and metabolism plays a central role in the pathophysiology of cardiovascular diseases, particularly heart failure, offering new therapeutic targets.
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