Key result
HF outreach program participation is linked to ~32% lower all-cause mortality.
Why the study?
Heart failure remains a major cause of morbidity and mortality despite management improvements, creating a need for non-pharmacological interventions to evaluate their impact on mortality, hospitalisations, and guideline-directed medical therapy.
Does a heart failure outreach programme reduce all-cause mortality in adult patients with HFrEF?
Observational (n=818)
Does a heart failure outreach programme reduce all-cause mortality in adult patients with HFrEF?
Absolute Event Rate: 26% vs 38.2%
p-value: p=<0.001
Participation in a heart failure outreach service is associated with reduced mortality, fewer hospitalizations, and higher rates of optimal guideline-directed medical therapy in patients with HFrEF.
BACKGROUND: Heart failure (HF) is a major cause of morbidity and mortality worldwide. Despite significant improvements in the management of HF, the overall outcome remains poor. In addition to pharmacotherapy and device therapy, non-pharmacological interventions are needed to mitigate the effects of this illness. The aim of this study was to evaluate the impact of the HF outreach programme on the rate of mortality, HF hospitalisations and guideline-directed medical therapy (GDMT) for HF in South-Western Sydney Local Health District (SWSLHD). METHODS: In this observational, registry-based study, adult patients diagnosed with HF with reduced ejection fraction (HFrEF) in SWSLHD were invited to participate in the HF outreach service between March 2011 and January 2016. The primary outcome was all-cause mortality. The secondary outcomes were the rate of optimal GDMT and HF hospitalisations. RESULTS: There were 818 patients included in the study; 470 (57.5%) patients were enrolled and 348 (42.5%) not enrolled into the programme. At the end of the follow-up period (median 978 days, IQR 720-1237), the primary outcome of mortality was observed less in the enrolled group (122 (26%) vs 133 (38.2%), p<0.001) independently of other variables. In addition, fewer enrolled patients had >3 hospital admissions for HF (16.2% vs 35.6%, p<0.001) and reduced median admission days (14.5 days (IQR 8-25) vs 22 days (IQR 12-37), p<0.001). Patients enrolled into the programme were more likely to be on optimal GDMT (76.6% vs 56.6%, p<0.001). CONCLUSIONS: Enrolment in the HF outreach programme was associated with a significant reduction in mortality and the frequency and length of hospital HF admissions. In addition, the rate of optimal GDMT was significantly higher in the enrolled group. With the high prevalence of HF, these programmes should be considered in the routine management of patients with HFrEF.
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Al-Falahi et al. (2025) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=818). Heart failure (HF) outreach programme vs. Not enrolled in the programme was evaluated on All-cause mortality (p=<0.001). Participation in a heart failure outreach programme was associated with significantly lower all-cause mortality compared to non-participation (26% vs 38.2%, p<0.001).
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