Key result
Prior preeclampsia is linked to suboptimal cardiovascular adaptation in parous women.
Why the study?
The effect of parity and previous preeclampsia on longitudinal maternal hemodynamics during pregnancy has not been studied.
Does parity and previous preeclampsia affect longitudinal maternal hemodynamics during pregnancy?
Observational
Does parity and previous preeclampsia affect longitudinal maternal hemodynamics during pregnancy?
A history of preeclampsia is associated with suboptimal maternal cardiovascular adaptation during subsequent pregnancies.
May warrant closer hemodynamic surveillance after preeclampsia; leaves open whether interventions improve outcomes.
BACKGROUND: The effect of parity and previous preeclampsia on the longitudinal maternal hemodynamics during pregnancy has not been studied. METHODS: weeks of gestation. The study populations were divided into 3 groups: nulliparous women and parous women with and without previous preeclampsia. A linear mixed-effects analysis was performed to compare the longitudinal changes in hemodynamics across gestation among the study groups, controlling for maternal characteristics and medical history in the index pregnancy. CONCLUSIONS: The study has revealed that parous women without previous preeclampsia show optimal cardiovascular responses. In contrast, those with a history of preeclampsia exhibit suboptimal cardiovascular adaptation, and the cardiovascular changes observed from the second trimester in the index pregnancy are attributed to maternal characteristics and the development of preeclampsia.
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Chen et al. (2025) conducted an observational in Pregnancy. Parity and previous preeclampsia vs. Nulliparous women and parous women without previous preeclampsia was evaluated on Longitudinal changes in maternal hemodynamics across gestation (p=<0.05). Parous women with a history of preeclampsia exhibit suboptimal cardiovascular adaptation compared to those without previous preeclampsia (P<0.05).
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