Key result
Abdominal obesity in HFpEF linked to higher mortality in males and more HF hospitalizations overall.
Why the study?
The association between abdominal obesity and the development of HFpEF between the sexes is not completely understood.
Does abdominal obesity increase the risk of all-cause mortality in male and female patients with HFpEF?
Cohort
Does abdominal obesity increase the risk of all-cause mortality in male and female patients with HFpEF?
Abdominal obesity is a sex-specific risk factor for all-cause mortality in men with HFpEF, while increasing the risk of heart failure hospitalization in both sexes.
Answers are grounded in this paper and cite their sources.
May inform sex-specific prognostication in HFpEF without altering management; extends observations but requires prospective validation.
Background: Association between abdominal obesity and development of heart failure (HF) with preserved ejection fraction (HFpEF) between the sexes is not completely understood. Objectives: This study evaluated the association between abdominal obesity and the risk of all-cause mortality in patients with HFpEF while performing a gender outcome comparison. Methods: A post hoc analysis was undertaken from the American cohort of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT). The primary outcome (all-cause mortality) and the secondary outcomes (cardiovascular mortality, hospitalization for HF, stroke, and MI) were evaluated via Cox proportional hazards models to compare the hazard ratios (HRs) between sexes in HFpEF patients. Abdominal obesity was defined as a waist circumference of ≥102 cm in men and ≥88 cm in women. Conclusions: Abdominal obesity is associated with increased risks of all-cause mortality in the male but not the female HFpEF population and is associated with increased risks of hospitalization for HF in both sexes.
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Fu et al. (2022) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF). Abdominal obesity (waist circumference ≥102 cm in men, ≥88 cm in women) vs. No abdominal obesity was evaluated on All-cause mortality (p== 0.010). Abdominal obesity was associated with an increased risk of all-cause mortality in male but not female patients with HFpEF (P=0.010), and increased risk of HF hospitalization in both sexes.
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