Key result
Intensive R-CEOP followed by R-CODOX-M/IVAC achieves complete metabolic remission in widespread HGBL-NOS involving 11 organs.
Why the study?
Disseminated extranodal involvement, absence of lymphadenopathy, and lack of standardized treatment guidelines pose significant diagnostic and therapeutic challenges in HGBL-NOS.
Population
One 27-year-old female with HGBL-NOS and disseminated extranodal involvement without lymphadenopathy
Design
Case report
Authors
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Should not yet change practice; hypothesis-generating for intensive regimens in rare multiorgan HGBL-NOS.
Case Report (n=1)
Intensive chemotherapy (R-CEOP followed by R-CODOX-M/IVAC) can achieve complete metabolic remission in rare, highly aggressive HGBL-NOS with extensive extranodal dissemination.
Sayes et al. (2026) conducted a case report in High-grade B-cell lymphoma, not otherwise specified (HGBL-NOS) (n=1). R-CEOP followed by R-CODOX-M/IVAC chemotherapy was evaluated on Complete metabolic remission. Intensive chemotherapy with R-CEOP followed by R-CODOX-M/IVAC achieved complete metabolic remission in a patient with widespread extranodal HGBL-NOS involving 11 organs.
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